“细绳松绑，师出有名”仁济医院创新转化启示录

2023年，在苏州国际博览中心的A馆，一位来自上海的泌尿科大主任正在为台下的数百名听众分享着手术机器人在泌尿外科手术中的临床应用现状。

他语速从容，也不需要照读PPT，时而用一些通俗的类比来讲解专精的术式，时而与台下的观众轻松互动来调剂注意力。在演讲台后插兜演讲的他，从容的仿佛一位脱口秀演员。笔挺的西装衬衫，在他身上贴合的就像一件没有标签的柔软白T，带着海派精英独有的自信和舒适感。

他叫薛蔚，是中国泌尿科顶尖临床专家之一。他所任职的医院，是上海开埠后的第一所西医医院，也是中国历史最悠久的综合性西医医院之一---上海交通大学附属仁济医院。

1844年，英国医师兼传教士雒魏林秉承着“中国医务传道会”在中国年轻人中传播医学的宗旨，在上海大东门租借的一所民居底楼中接待了第一位上海病人。诊所虽然很小，且接收能力有限，但因其平民化和免费医疗而吸引了上海、苏州、松江和周边，甚至远至崇明岛的患者前来。

这个诊所不仅是沪上西医诊所的开端，也是上海仁济医院的前身。诊所几经扩张，而后改名为“仁济医馆”，取仁术济世之意。据当年上海《申报》报道，仁济医馆在前两年接诊病人高达1.9万人次。

仁术济世之意延续至今天。如今，上海交通大学附属仁济医院已经发展成了具有53个临床医技科室，2750张床位，四个院区，一个肿瘤研究所的集医疗、教学、科研于一体的综合性三级甲等医院。

不知是否是来自于上海地区对生活质量更高的认知和标准，仁济医院的优势科室对此一脉相承。

仁济医院拥有全国排名第一的消化科，现有病床112张，仅内镜中心就占地3400平方米，实验室面积达1200平方米。2023年，科室门诊患者人数达70万余人次，消化内镜检查人数达26.7万人次，接诊数量为全国第一。

在科研方面，仁济消化内科2023年累计发表SCI论文62篇，其中10篇IF>20（NEJM、Cancer Cell、Cell Host Microbe、Cell Metabolism、Nat Microbiology、Journal of Hepatology 、GUT等）。副院长房静远教授带领下的消化内科团队也牵头制定并发表了多项国内外的临床共识与诊治指南。

仁济医院风湿病科同样为全国优势学科，有床位数71张，2023年门诊量接近30万人次，年出院人数超过5000人，其中70%为疑难危重患者，连续5年为国内门诊量最大的风湿病专科。在风湿科主任沈南教授的领导下，团队于2023年发表Science1篇，14篇IF>10（Annals of the Rheumatic Diseases、Arthritis & Rheumatology、Advanced Science等），继续夯实了科室于系统性红斑狼疮诊治的国际领先队列位置。

同为全国优势学科的还有开篇副院长薛蔚教授带领的仁济医院泌尿外科。年门诊量超过40万人次，手术量超过2万例，大和特大手术占60%以上。作为拥有多个优势亚专业（肾脏肿瘤、前列腺肿瘤、膀胱肿瘤）的临床中心，仁济医院泌尿外科是公认的全国乃至世界领先的泌尿诊疗中心之一。

这些优势科室的影响力也主动渗透向了周边地区。2003年由仁济医院倡议并联合社会资本创办的仁济医疗集团，依托仁济医院的优势品牌，通过投资和托管等形式，在专家派遣上采取常驻、定期和临时会诊等多种方式在周边地方医院进行管理模式和技术资源输出。如今，集团已运营超过20余家二级及以上医院，布局了上海周边车程3小时、高铁1小时的长三角地区。

手术技术奠定了仁济医院惊人的长板，也是各科室得以在临床实践中寻求科研创新突破的所在。

在科研水平上，仁济医院同样表现不俗。仁济医院在Nature自然指数医院科研实力排行榜中，常年保持中国区第二名的水平，在各科室专长的细分领域均有代表性的高被引文章问世。在刚刚过去的2023年，仁济医院也以150项国自然立项位居全国第五，表现不俗。

但对于国内医院“临床是临床，文章是文章，成果不老少，未必用得上”的问题，仁济医院是如何解决的呢？

2019年，上海交通大学医学院附属仁济医院临床研究中心、上海交通大学医学院临床研究中心仁济医院分中心正式揭牌成立。

中心每年投入3000万经费，打造了一个以研究者为核心，提供临床研究全生命周期支持服务，链接生物医药产业上下游的创新中心。这是仁济医院副院长戴慧莉教授为了推动各优势科室的学科融合，完善科研平台建设，并加快临床研究发展和水平提升的重要布局。

政策方面，仁济医院在这期间也相继推出《仁济医院促进科技成果转化管理办法》、《仁济医院科研激励绩效管理办法》、《仁济医院知识产权保护管理规定》等一系列明文政策来为临床人员捋清过往公立医院成果转化灰色地带不明晰的历史症结。

而对于院内人员，医院管理层也在为他们做着热身工作。定期的知识产权资产评估、成果转化线上培训课程、科研处每年为期一个月的专利成果巡回展、与上海技术交易所签订的平台搭建框架协议，快速的为院内人员营造出了成果转化的良好氛围。

软硬件的配合，加之仁济医院陆续搭建的一系列如肿瘤系统医学全国重点实验室、分子医学研究院、免疫创新研究院、衰老与组织修复研究院等高水平基础研究平台，如同排列好的多米诺骨牌一般，积累着势能，等待着释放。

很快，推倒第一块多米诺骨牌的一刻便来临了。

2022年，上海市科委、市卫健委等八部门联合印发《上海市促进医疗卫生机构科技成果转化操作细则（试行）》，以促进医疗卫生机构科技成果转化。

用戴慧莉教授的话来说，此次的《细则》为束缚医疗机构的“细绳子松了绑”，也让成果转化终于“师出有名”。有了官方的明确认可，一系列此前有灰色地带标签的市场化行为终于得以展开。

《细则》的推出如同一个分水岭，记录了仁济医院积累的临床势能如何开始在创新成果转化上释放。

《细则》推出的同月，仁济医院就宣布与联影医疗升级战略合作，共建创新转化医学中心。同时，双方也发布了仁济-联影分子影像研发中心合作研发的诸多最新进展。

作为全国首家“产学研医”为一体的创新型分子影像研发中心，仁济-联影分子影像研发中心自建立之初就着眼于国产医疗设备的卡脖子问题，围绕“基于多模态表观弥散磁共振成像”、“基于UEXPLORER进行诊疗一体化显像并估算剂量”、“PET/MR联合重建技术”等多个研究方向至今已推进了15项临床研究项目和2项临床注册试验项目。企业联动，扎实而又多产。

2023年，仁济医院与张江医学园深度绑定，主动寻求与张江园区内的诸多优秀企业建立长久的联动机制，促进企业内的创新研发人员与仁济医院内的临床科研人员深入的互动，保持对成果转化需求的有效沟通，在顶层设计中与张江园区内企业保持高质量同频。生态的建设，稳步且具有前瞻性。

优秀成果的转化落地，也同样接连不断。

2022年，仁济医院与国药集团下属成员企业上海鑫合医药就“丁烯酸内酯类化合物的制备方法和用途”的专利技术签署了科技成果转让协议，转让金额1000万元。发明人林厚文教授为仁济医院药剂科主任，从真菌发酵物中发现了一系列新颖结构的丁烯酸内酯化合物，为开发治疗糖尿病及炎症的药物提供了新的候选化合物。

2023年，仁济医院与某医学检验技术公司就“一种用于检测星座链球菌的试剂及临床应用”的专利技术签署了科技成果转让协议，转让金额260万元。发明人房静远教授团队借用新型生物标记物的发现，实现了胃癌筛查与预警的新方式，为胃癌的二级预防提供了新的检测技术与筛查策略。

2024年，仁济医院与上海埃立孚医疗科技有限公司就“一种内窥镜手术专用口咽通道”的专利技术签署了成果转化协议。发明人苏殿三教授专攻无痛胃肠镜麻醉的气道管理，其专利技术有效的降低了无痛胃肠镜麻醉中低氧事件的发生，大大提高了病人的舒适度和安全性。

没有了枷锁的束缚，仁济医院很快便发挥出了上海地区的市场化特色，在创新转化中寻得了一片繁花。

不难看出，历史悠久且具有传统优势科室的仁济医院，其在成果转化上的创新与成绩是围绕2022年《细则》的出台而集中展开的。

在内功方面，仁济有着毋庸置疑的临床水平和多个院区带来的实践土壤。临床科研和临床实践在海量的实践操作中相辅相成。医院管理层也对于成果转化的内部制度和流程进行了时间充足的共识建立。

外部联动和建设方面，借助上海及周边地区惯有的市场化特色，仁济的各科室在更小颗粒度的微观层面长期与市场保持了紧密的沟通与临床合作。

在市委及国家层面更加明确的调理推出后，以仁济为代表的一批医院及临床工作者对于与行业和市场的双向奔赴终于有了正式的名分，自由度和灵活度都大大提升。相信2022年对于仁济医院的成果走向市场将会成为一个标志性的时间点。

20（NEJM、Cancer Cell、Cell Host Microbe、Cell Metabolism、Nat Microbiology、Journal of Hepatology 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